After the death of their boss, Beatrix, Cain and Harold are left destitute living in an abandoned grocery store. Beatrix is determined that they will fight on their own and take over the world by any means necessary.

Aisha Tyler apresenta este programa de comédia onde os atores do programa, normalmente Wayne Brady, Colin Mochrie, Ryan Stiles e outra estrela convidada ou duas fazem séries de comédia diferentes.