Jessica returns home after college to find that her single mother, Tracy's new boyfriend, Paul, is also moving in. Jess soon suspects he is not who he seems, and she sets out to prove that he's the wrong Mr Right.

The moment Riley meets Chris, she thinks he is handsome, charming and affectionate. He seems perfect, but after a party at his house, Riley sees that Chris has a darker side.

Chris Redfield, da BSAA, pede ajuda ao agente do governo Leon S. Kennedy e à professora Rebecca Chambers, do Instituto de Biotecnologia Alexander, para impedir que um mercador da morte vingativo espalhe um vírus mortal em Nova York.