Em uma penitenciária de última geração, um detento participa de um experimento com drogas que controlam as emoções para um gênio da indústria farmacêutica.

Emily is a recovering cancer survivor of three years. Faced with her fear of getting sick again, her best friend Nina plans a weekend away. Six friends venture out to a country holiday house to party over a weekend. Cut off from the rest of the world they soon learn the inhabitants are unsettling red neck individuals who terrorize and humiliate travelers. At the same time a para-normal monster seen as the faceless man haunts the house pushing the friends to their limits.