Uma atrapalhada mulher com mais de 30 anos (Amy Schumer) tem uma vida amorosa desastrosa. Sua rotina se resume em casos de uma noite só e beber com os amigos, mas tudo pode mudar quando ela acaba conhecendo um médico desportivo (Bill Hader) que parece ser o "cara ideal".

Over fifty very famous American, Canadian, British and Australian funny people (filmmakers, writers, actors and comedians) share life and professional journeys and insights, in an effort to shed light on the thesis: Do you have to be miserable to be funny?

Nothing is off limits for Amy Schumer in her first original one-hour stand-up special. Schumer airs every hilarious, messed-up detail of her dating and sex life, from encounters with unexpected body parts to hate-filled personal grooming appointments.